Synthesis of new chiral 1,3-aminoalcohols derived from levoglucosenone and their application in asymmetric alkylations

TETRAHEDRON LETTERS

卷:56

Article

Zanardi, Maria M.¹  Suarez, Alejandra G.¹ 

[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Rosario, RA-2000 Rosario, Santa Fe, Argentina

关键词: Levoglucosenone;    1,3-Aminoalcohols;    Chiral ligands;    Asymmetric induction;   

DOI  :  10.1016/j.tetlet.2015.04.051

来源: Elsevier

【 摘 要 】

We have developed a simple procedure for the preparation of chiral 1,3-aminoalcohols using the biomass derivative levoglucosenone, as the chiral starting material. 1,3-aminoalcohols, bearing primary and tertiary amino groups, were tested as chiral catalysts in the asymmetric addition of diethyl zinc to benzaldehyde. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free