Challenging synthesis of bisphosphonate derivatives with reduced steric hindrance

TETRAHEDRON LETTERS

卷:70

Article

Chiminazzo, Andrea¹  Sperni, Laura¹  Fabris, Fabrizio¹  Scarso, Alessandro¹ 

[1] Univ Ca Foscari Venezia, Dipartimento Sci Mol & Nanosistemi, Via Torino 155, I-30172 Venice, Ve, Italy

关键词: Bisphosphonates;    Protection methods;    Precursors;    Osteoporosis;    Orthoformate;   

DOI  :  10.1016/j.tetlet.2021.153012

来源: Elsevier

【 摘 要 】

An alternative approach is reported for the synthesis of methyl ester protected bisphosphonate building blocks, such as methylene bisphosphonate, vinylidenebisphosphonate and aryl substituted prochiral vinylidenebisphosphonates, that cannot be obtained directly from dimethyl phosphite and dichloromethane. (C) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

Free