Development of one-pot benzylic amination reactions of azine N-oxides

TETRAHEDRON LETTERS

卷:59

Article

Liman, Menekse¹  Turkmen, Yunus Emre^1,2,3 

[1] Bilkent Univ, Fac Sci, Dept Chem, TR-06800 Ankara, Turkey

[2] Bilkent Univ, UNAM, Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey

[3] Bilkent Univ, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey

关键词: Azine N-oxides;    Benzylic amination;    One-pot synthesis;    Heteroaromatic compounds;    Amines;   

DOI  :  10.1016/j.tetlet.2018.03.062

来源: Elsevier

【 摘 要 】

An efficient one-pot synthetic methodology has been developed for the benzylic amination reactions of methyl-substituted azine N-oxides that operate under mild conditions. The reaction was found to tolerate quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partners as well as a broad range of nucleophilic primary, secondary and aromatic amines, affording the benzylic amination products in up to 82% yield. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

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