An alternative route to tethered Ru(II) transfer hydrogenation catalysts

TETRAHEDRON LETTERS

卷:59

Article

Hodgkinson, Roy¹  Jurcik, Vaclav²  Nedden, Hans²  Blackaby, Andrew²  Wills, Martin¹ 

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Johnson Matthey, Catalysis & Chiral Technol, 28 Cambridge Sci Pk, Cambridge CB4 0FP, England

关键词: Ruthenium;    Catalyst;    Tethered;    Reduction;    Alcohol;    Hydrogenation;   

DOI  :  10.1016/j.tetlet.2018.01.071

来源: Elsevier

【 摘 要 】

A new route towards a series of tethered eta(6)-arene/Ru(II) catalysts for use in the transfer and pressure hydrogenation of ketones and aldehydes to alcohols is reported. The route proceeds through the formation of an amide from the diamine precursor, followed by reduction, rather than the direct alkylation of the diamine. This has the advantage that dialkylation of the amine is avoided during the synthesis. Through this new route, both racemic and enantiomerically-pure eta(6)-arene/Ru(11) tethered catalysts can be prepared in high yield. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

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