期刊论文详细信息
TETRAHEDRON LETTERS 卷:56
Self-propagated Lossen rearrangement induced by a catalytic amount of activating agents under mild conditions
Article
Hoshino, Yujiro1  Shimbo, Yuki1  Ohtsuka, Naoya1  Honda, Kiyoshi1 
[1] Yokohama Natl Univ, Grad Sch Environm & Informat Sci, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan
关键词: Lossen rearrangement;    Hydroxamic acids;    Amines;    Activating agents;   
DOI  :  10.1016/j.tetlet.2014.12.084
来源: Elsevier
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【 摘 要 】

A mild self-propagated Lossen rearrangement induced by a catalytic amount of activating agents in medium to high polar organic solvents has been developed. The rearrangement of aromatic and aliphatic hydroxamic acids in the presence of a catalytic amount (0.01 equiv) of acetic anhydride and an equimolar amount of base such as well-dried potassium carbonate afforded the corresponding amines in high yields. This alternative to traditional Lossen rearrangement provides a simple and mild method for the synthesis of amines from free hydroxamic acids. (C) 2014 Elsevier Ltd. All rights reserved.

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