TETRAHEDRON LETTERS | 卷:56 |
Self-propagated Lossen rearrangement induced by a catalytic amount of activating agents under mild conditions | |
Article | |
Hoshino, Yujiro1  Shimbo, Yuki1  Ohtsuka, Naoya1  Honda, Kiyoshi1  | |
[1] Yokohama Natl Univ, Grad Sch Environm & Informat Sci, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan | |
关键词: Lossen rearrangement; Hydroxamic acids; Amines; Activating agents; | |
DOI : 10.1016/j.tetlet.2014.12.084 | |
来源: Elsevier | |
【 摘 要 】
A mild self-propagated Lossen rearrangement induced by a catalytic amount of activating agents in medium to high polar organic solvents has been developed. The rearrangement of aromatic and aliphatic hydroxamic acids in the presence of a catalytic amount (0.01 equiv) of acetic anhydride and an equimolar amount of base such as well-dried potassium carbonate afforded the corresponding amines in high yields. This alternative to traditional Lossen rearrangement provides a simple and mild method for the synthesis of amines from free hydroxamic acids. (C) 2014 Elsevier Ltd. All rights reserved.
【 授权许可】
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【 预 览 】
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