Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

TETRAHEDRON LETTERS

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Article

Alapafuja, Shakiru O.¹  Nikas, Spyros P.¹  Shukla, Vidyanand G.¹  Papanastasiou, Ioannis¹  Makriyannis, Alexandros¹ 

[1] Northeastern Univ, Ctr Drug Discovery, Boston, MA 02115 USA

关键词: Sodium sulfonates;    Microwave;    Sulfonyl chlorides;    Sulfonyl fluorides;   

DOI  :  10.1016/j.tetlet.2009.09.167

来源: Elsevier

【 摘 要 】

We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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