Diphosphate formation using cyanuric chloride or triisopropylbenzenesulfonyl chloride as the activating agents

TETRAHEDRON LETTERS

卷:52

Article

Lin, Teng-Chi¹  Fang, Jim-Min¹ 

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

关键词: Diphosphate compounds;    Cyanuric chloride;    2,4,6-Triisopropylbenzenesulfonyl chloride;    Phosphate coupling reaction;   

DOI  :  10.1016/j.tetlet.2011.01.034

来源: Elsevier

【 摘 要 】

By using cyanuric chloride or 2,4,6-triisopropylbenzenesulfonyl chloride (TIPSCl) as the condensing agent and magnesium bromide as the promoter, the phosphate cross-coupling reactions are effectively carried out to give lipid-saccharide and pyrrolidine-guanosine diphosphates. Under optimized conditions, the TIPSCl-facilitated cross-coupling reactions complete in a short reaction time (similar to 5 h) without the complication of possible self-coupling reactions. (c) 2011 Elsevier Ltd. All rights reserved.

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