The use of aqueous potassium dichloroiodate for the synthesis of ureas

TETRAHEDRON LETTERS

卷:54

Article

Viana, Gil Mendes¹  de Sequeira Aguiar, Lucia Cruz¹  Ferrao, Jonas de Araujo¹  Costa Simas, Alessandro Bolis²  Vasconcelos, Marcela Guariento² 

[1] Univ Fed Rio de Janeiro, Inst Quim, CT, BR-21941909 Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, NPPN, CCS, BR-21941902 Rio De Janeiro, RJ, Brazil

关键词: Ureas;    Potassium dichioroiodate;    Oxidation;    Halogenation;   

DOI  :  10.1016/j.tetlet.2012.12.045

来源: Elsevier

【 摘 要 】

We report a straightforward and efficient reaction protocol for the syntheses of substituted ureas via treatment of thioureas with aqueous potassium dichloroiodate (KICl2). By tuning the reaction condition, thioureas bearing activated N-aryl substituents may undergo either selective oxidation or sequential oxidation and iodination, forming iodoaryl ureas in the latter case. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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