Isolation of amoenamide A and five antipodal prenylated alkaloids from Aspergillus amoenus NRRL 35600

TETRAHEDRON LETTERS

卷:58

Article

Sugimoto, Kayo¹  Sadahiro, Yusaku¹  Kagiyama, Ippei¹  Kato, Hikaru¹  Sherman, David H.^2,3,4,5  Williams, Robert M.^6,7  Tsukamoto, Sachiko¹ 

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Oe Honmachi 5-1, Kumamoto, Kumamoto 8620973, Japan

[2] Univ Michigan, Inst Life Sci, 210 Washtenaw Ave, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Med Chem, 210 Washtenaw Ave, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Chem, 210 Washtenaw Ave, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Microbiol & Immunol, 210 Washtenaw Ave, Ann Arbor, MI 48109 USA

[6] Colorado State Univ, Dept Chem, 1301 Ctr Ave, Ft Collins, CO 80523 USA

[7] Univ Colorado, Canc Ctr, Aurora, CO 80045 USA

关键词: Alkaloid;    Aspergillus;    Fungus;    Antipode;   

DOI  :  10.1016/j.tetlet.2017.05.057

来源: Elsevier

【 摘 要 】

A new prenylated alkaloid, Amoenamide A (6), was isolated from the fungus Aspergillus amoenus NRRL 35600. Previously, 6 was postulated to be a precursor of Notoamide E4 (21) converted from Notoamide E (16), which was a key precursor of the prenylated indole alkaloids in the fungi of the genus Aspergillus. We previously succeeded in the isolation of two pairs of antipodes, Stephacidin A (1) and Notoamide B (2), from A. amoenus and A. protuberus MF297-2 and expected the presence of other antipodes in the culture of A. amoenus. We here report five new antipodes (7-11) along with a new metabolite (12), which was isolated as a natural compound for the first time, from A. amoenus. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free