Rapid synthesis of the indole-indolone scaffold via [3+2] annulation of arynes by methyl indole-2-carboxylates

TETRAHEDRON LETTERS

卷:50

Article

Rogness, Donald C.¹  Larock, Richard C.¹ 

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

关键词: Aryne;    Annulation;    Indole;   

DOI  :  10.1016/j.tetlet.2009.04.047

来源: Elsevier

【 摘 要 】

The reaction of methyl indole-2-carboxylates and arynes affords a very efficient, high yielding synthesis of a novel indole-indolone ring system, which tolerates considerable functionality, is broad in scope, and proceeds under mild reaction conditions. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

Free