The [18F]2-fluoro-1,3-thiazolyl moiety-an easily-accessible structural motif for prospective molecular imaging radiotracers

TETRAHEDRON LETTERS

卷:51

Article

Simeon, Fabrice G.¹  Wendahl, Matthew T.¹  Pike, Victor W.¹ 

[1] NIMH, Mol Imaging Branch, NIH, Bethesda, MD 20892 USA

关键词: Radiofluorination;    1,3-Thiazole;    Microwave-assisted synthesis;   

DOI  :  10.1016/j.tetlet.2010.09.037

来源: Elsevier

【 摘 要 】

2-Fluoro-1,3-thiazoles were rapidly and efficiently labeled with no-carrier-added fluorine-18 (t(1/2) = 109.7 min) by treatment of readily prepared 2-halo precursors with cyclotron-produced [F-18]fluoride ion. The [F-18]2-fluoro-1,3-thiazolyl moiety constitutes a new and easily-labeled structural motif for prospective molecular imaging radiotracers. Published by Elsevier Ltd.

【 授权许可】

Free