Simple and efficient protocol for the synthesis of novel dihydro-1H-pyrano[2,3-c]pyrazol-6-ones via a one-pot four-component reaction

TETRAHEDRON LETTERS

卷:53

Article

Azzam, Sadeq Hamood Saleh¹  Pasha, M. A.¹ 

[1] Bangalore Univ, Dept Studies Chem, Bengaluru 560001, Karnataka, India

关键词: Pyranopyrazole-6-ones;    Aromatic aldehydes;    Meldrums acid;    Ethyl acetoacetate;    Hydrazine hydrate;    Ba(OH)(2);    Water;   

DOI  :  10.1016/j.tetlet.2012.10.025

来源: Elsevier

【 摘 要 】

Ba(OH)(2) catalyzed simple and efficient one-pot four-component reaction of Meldrums acid, ethyl acetoacetate, hydrazine hydrate, and aromatic aldehydes to give 3-methyl-4-aryl-4,5-dihydro-1H-pyrano[2,-3c]pyrazol-6-ones in refluxing water is reported. The yields are high and the reactions go to completion in 1-2 h. (C) 2012 Elsevier Ltd. All rights reserved.

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