Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases

Frontiers in Molecular Biosciences

Molecular Biosciences

Shengliang Peng¹  Bin Hu²  Xiaoqing Cheng²  Lidong Wu²  Jialing Hu²  Danling Jiang³  Yiqian Huang⁴  Yi Xu⁴ 

[1] Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China;Department of Emergency Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China;Department of Ultrasound Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China;The Second Affiliated Hospital of Nanchang University, The Second Clinical Medical College of Nanchang University, Nanchang, China;

关键词: Piezo1;    Piezo2;    therapeutic target;    fibrosis;    Ca2+;   

DOI  :  10.3389/fmolb.2023.1270979

 received in 2023-08-11, accepted in 2023-09-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Fibrosis could happen in every organ, leading to organic malfunction and even organ failure, which poses a serious threat to global health. Early treatment of fibrosis has been reported to be the turning point, therefore, exploring potential correlates in the pathogenesis of fibrosis and how to reverse fibrosis has become a pressing issue. As a mechanism-sensitive cationic calcium channel, Piezo1 turns on in response to changes in the lipid bilayer of the plasma membrane. Piezo1 exerts multiple biological roles, including inhibition of inflammation, cytoskeletal stabilization, epithelial-mesenchymal transition, stromal stiffness, and immune cell mechanotransduction, interestingly enough. These processes are closely associated with the development of fibrotic diseases. Recent studies have shown that deletion or knockdown of Piezo1 attenuates the onset of fibrosis. Therefore, in this paper we comprehensively describe the biology of this gene, focusing on its potential relevance in pulmonary fibrosis, renal fibrosis, pancreatic fibrosis, and cardiac fibrosis diseases, except for the role of drugs (agonists), increased intracellular calcium and mechanical stress using this gene in alleviating fibrosis.

【 授权许可】

Unknown   
Copyright © 2023 Xu, Huang, Cheng, Hu, Jiang, Wu, Peng and Hu.