Ankylosing spondylitis and psychiatric disorders in European population: a Mendelian randomization study

Frontiers in Immunology

Immunology

Huifang Zuo¹  Min-Min Li¹ 

[1] Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China;

关键词: ankylosing spondylitis;    psychiatric disorders;    Mendelian randomization;    major depression;    anxiety disorder;    schizophrenia;    bipolar disorder;    anorexia nervosa;   

DOI  :  10.3389/fimmu.2023.1277959

 received in 2023-08-15, accepted in 2023-10-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundEpidemiologic evidence has demonstrated a correlation between ankylosing spondylitis and psychiatric disorders. However, little is known about the common genetics and causality of this association. This study aimed to investigate the common genetics and causality between ankylosing spondylitis (AS) and psychiatric disorders.MethodsA two-sample Mendelian Randomization (MR) analysis was carried out to confirm causal relationships between ankylosing spondylitis and five mental health conditions including major depressive disorder (MDD), anxiety disorder (AXD), schizophrenia (SCZ), bipolar disorder (BIP), and anorexia nervosa (AN). Genetic instrumental variables associated with exposures and outcomes were derived from the largest available summary statistics of genome-wide association studies (GWAS). Bidirectional causal estimation of MR was primarily obtained using the inverse variance weighting (IVW) method. Other MR methods include MR-Egger regression, Weighted Median Estimator (WME), Weighted Mode, Simple Mode, and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO). Sensitivity analyses are conducted to estimate the robustness of MR results.ResultsThe findings suggest that AS may be causally responsible for the risk of developing SCZ (OR = 1.18, 95% confidence interval = (1.06, 1.31), P = 2.58 × 10-3) and AN (OR = 1.32, 95% confidence interval = (1.07, 1.64), P = 9.43 × 10-3). In addition, MDD, AXD, SCZ, AN, and BIP were not inversely causally related to AS (all p > 0.05).ConclusionOur study provides fresh insights into the relationship between AS and psychiatric disorders (SCZ and AN). Furthermore, it may provide new clues for risk management and preventive interventions for mental disorders in patients with AS.

【 授权许可】

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Copyright © 2023 Zuo and Li