Protocol for a 20-year follow-up after a randomized controlled trial of a Mediterranean diet in pregnancy: maternal and offspring risk factors for cardiovascular disease

Frontiers in Pediatrics

Pediatrics

Jeanine Roeters van Lennep¹  Hannibal Troensegaard²  Janette Khoury²  Per Ole Iversen³  Kirsten B. Holven⁴  Kjetil Retterstøl⁵  Ane C. Westerberg⁶  Serena Tonstad⁷  Marit B. Veierød⁸ 

[1] Department of Internal Medicine, Erasmus MC Cardiovascular Institute, University Medical Centre Rotterdam, Rotterdam, Netherlands;Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;Department of Haematology, Oslo University Hospital, Oslo, Norway;Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;Norwegian National Advisory Unit on Familial Hypercholesterolemia, Oslo University Hospital, Oslo, Norway;Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;The Lipid Clinic, Department of Medicine, Oslo University Hospital, Oslo, Norway;Department of Obstetrics, Division of Obstetrics and Gynaecology, Oslo University Hospital Rikshospitalet, Oslo, Norway;School of Health Sciences, Kristiania University College, Oslo, Norway;Department of Preventive Cardiology, Oslo University Hospital, Oslo, Norway;Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;

关键词: cardiovascular risk factors;    offspring health;    antenatal care;    lifestyle intervention;    Mediterranean diet;    long-term follow-up;    pregnancy;    randomized controlled trial;   

DOI  :  10.3389/fped.2023.1256815

 received in 2023-07-11, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundAn inadequate maternal diet during pregnancy can impair offspring health and may increase the risk of cardiovascular disease later in life. The purpose of the proposed study is to assess the risk factors associated with cardiovascular disease in both mothers and their offspring 20 years following their participation in a Mediterranean diet intervention trial during pregnancy.MethodsThe “Cardiovascular Risk Reduction Diet In Pregnancy” (CARRDIP) study was a randomized controlled trial performed between 1999 and 2001. The participants were randomized to adhere to either a Mediterranean diet or their regular diet during pregnancy. An extensive amount of data such as diet information, ultrasound measurements, anthropometry, and biomarkers from these mothers during pregnancy and their offspring in the neonatal period were collected. The mother–offspring pairs (n = 269) from the CARRDIP study will be invited to participate in a clinical examination and blood sample collection. This follow-up study, conducted 20 years after the original CARRDIP study, will investigate cardiovascular risk factors in mothers and offspring. The primary outcome will be the blood pressure of the offspring. In addition, the study will explore various aspects of cardiovascular health, including metabolic and inflammatory status, clinical history, and body composition of the participants.DiscussionPrevious studies investigating the effects of nutrition during pregnancy on maternal and offspring health have been either observational studies, animal studies, or randomized controlled trials with a follow-up period of less than 5 years. This project aims to study the long-term effects of dietary intervention during pregnancy on maternal and offspring cardiovascular risk markers.Clinical Trial RegistrationClinicaltrials.gov, identifier (NCT05030922).

【 授权许可】

Unknown   
© 2023 Troensegaard, Khoury, Westerberg, Tonstad, Roeters van Lennep, Veierød, Iversen, Holven and Retterstøl.