Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game

Frontiers in Immunology

Immunology

Mateusz Marciniak¹  Marek Wagner² 

[1] Cancer Biomarkers Research Group, Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wrocław, Poland;Cancer Biomarkers Research Group, Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wrocław, Poland;Department of Biomedicine, University of Bergen, Bergen, Norway;

关键词: innate lymphoid cells;    skin;    skin cancer;    melanoma;    lactic acid;    lactate;    metabolism;   

DOI  :  10.3389/fimmu.2023.1236301

 received in 2023-06-08, accepted in 2023-09-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

Aerobic glycolysis, also known as the Warburg effect, has for a prolonged period of time been perceived as a defining feature of tumor metabolism. The redirection of glucose utilization towards increased production of lactate by cancer cells enables their rapid proliferation, unceasing growth, and longevity. At the same time, it serves as a significant contributor to acidification of the tumor microenvironment, which, in turn, imposes substantial constraints on infiltrating immune cells. Here, we delve into the influence of tumor-derived lactic acid on innate lymphoid cells (ILCs) and discuss potential therapeutic approaches. Given the abundance of ILCs in barrier tissues such as the skin, we provide insights aimed at translating this knowledge into therapies that may specifically target skin cancer.

【 授权许可】

Unknown   
Copyright © 2023 Marciniak and Wagner