Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia

Frontiers in Neurology

Neurology

Samir Kanaan Nabhan¹  Hélio Afonso Ghizoni Teive²  Dora Pedroso Kowacs³  Caio César Diniz Disserol⁴  Pedro André Kowacs⁴ 

[1] Blood and Marrow Transplantation Program, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil;Department of Neurology, Complexo do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil;Department of Neurology, Instituto de Neurologia de Curitiba, Curitiba, Brazil;Department of Neurology, Instituto de Neurologia de Curitiba, Curitiba, Brazil;Department of Neurology, Complexo do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil;

关键词: autoimmune diseases of the nervous system;    dementia;    encephalitis;    glutamic acid decarboxylase;    neurocognitive disorders;   

DOI  :  10.3389/fneur.2023.1254981

 received in 2023-07-11, accepted in 2023-09-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease.

【 授权许可】

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Copyright © 2023 Disserol, Kowacs, Nabhan, Teive and Kowacs.