Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis

Frontiers in Human Neuroscience

Human Neuroscience

Chao Zhou¹  Zixu Wang¹  Xinyu Fang¹  Yuru Ling¹  Xiangrong Zhang²  Zengxiu Wang³  Weifeng Wu³  Chunming Xie⁴  Tingting Zhu⁵  Chengbing Huang⁵  Jiu Chen⁶ 

[1] Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China;Department of Hepatology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China;Department of Neurology, Affiliated Zhongda Hospital, School of Medicine Southeast University, Nanjing, China;Department of Psychiatry, The Third People’s Hospital of Huai’an, Huaian, Jiangsu, China;Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;

关键词: persistent negative symptoms;    functional connectivity;    gray matter volume;    default mode network;    central executive network;    salience network;   

DOI  :  10.3389/fnhum.2023.1204632

 received in 2023-04-12, accepted in 2023-10-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveTo investigate brain structural and functional characteristics of three brain functional networks including default mode network (DMN), central executive network (CEN), and salience network (SN) in persistent negative symptoms (PNS) patients.MethodsWe performed an activation likelihood estimation (ALE) meta-analysis of functional connectivity (FC) studies and voxel-based morphometry (VBM) studies to detect specific structural and functional alterations of brain networks between PNS patients and healthy controls.ResultsSeventeen VBM studies and twenty FC studies were included. In the DMN, PNS patients showed decreased gray matter in the bilateral medial frontal gyrus and left anterior cingulate gyrus and a significant reduction of FC in the right precuneus. Also, PNS patients had a decrease of gray matter in the left inferior parietal lobules and medial frontal gyrus, and a significant reduction of FC in the bilateral superior frontal gyrus in the CEN. In comparison with healthy controls, PNS patients exhibited reduced gray matter in the bilateral insula, anterior cingulate gyrus, left precentral gyrus and right claustrum and lower FC in these brain areas in the SN, including the left insula, claustrum, inferior frontal gyrus and extra-nuclear.ConclusionThis meta-analysis reveals brain structural and functional imaging alterations in the three networks and the interaction among these networks in PNS patients, which provides neuroscientific evidence for more personalized treatment.Systematic Review RegistrationThe PROSPERO (https://www.crd.york.ac.uk/PROSPERO/, registration number: CRD42022335962).

【 授权许可】

Unknown   
Copyright © 2023 Zhu, Wang, Wu, Ling, Wang, Zhou, Fang, Huang, Xie, Chen and Zhang.