FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review

Frontiers in Oncology

Oncology

Zenan Hu¹  Yuping Wang¹  Yongning Zhou¹  Xiaolong Tang²  Xiangqing Ren³  Tian Huang³ 

[1] Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China;Gansu Province Clinical Research Center for Digestive Diseases, The First Hospital of Lanzhou University, Lanzhou, China;The First Clinical Medical College, Lanzhou University, Lanzhou, China;The First Clinical Medical College, Lanzhou University, Lanzhou, China;Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China;Gansu Province Clinical Research Center for Digestive Diseases, The First Hospital of Lanzhou University, Lanzhou, China;

关键词: FTO;    m6A;    gastrointestinal cancer;    immunotherapy;    tumor microenvironment;   

DOI  :  10.3389/fonc.2023.1241357

 received in 2023-06-16, accepted in 2023-09-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis. Therefore, developing novel effective markers and therapeutic targets for gastrointestinal cancer is currently a challenging and popular topic in oncology research. Accumulating studies have reported that N6-methyladenosine is the most abundant epigenetic modification in eukaryotes. N6-methyladenosine plays an essential role in regulating RNA expression and metabolism, including splicing, translation, stability, decay, and transport. FTO, the earliest demethylase discovered to maintain the balance of N6-adenosine methylation, is abnormally expressed in many tumors. In this review, we discuss the molecular structure and substrate selectivity of FTO. we focus on the role of FTO in gastrointestinal tumor proliferation, migration, invasion, apoptosis, autophagy, immune microenvironment, and its molecular mechanisms. We also discuss its potential in the treatment of gastrointestinal cancers.

【 授权许可】

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Copyright © 2023 Ren, Tang, Huang, Hu, Wang and Zhou