Calcium sulfate-Cu2+ delivery system improves 3D-Printed calcium silicate artificial bone to repair large bone defects

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Feifei Yan¹  Qingjian Lei¹  Linlong Wang¹  Jiawen Li¹  Yan Chen¹  Chao Hu¹  Huayi Huang¹  Lingfei Xiao¹  Renxiong Wei¹  Shijie Gao¹  Tie Zhang² 

[1]Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

[2]Wuhan QISIDA Technology Development Co., Ltd., Wuhan, Hubei, China

关键词: 3D printing;    calcium silicate;    calcium sulfate;    Cu2+;    bone repair;   

DOI  :  10.3389/fbioe.2023.1224557

 received in 2023-05-17, accepted in 2023-09-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

There are still limitations in artificial bone materials used in clinical practice, such as difficulty in repairing large bone defects, the mismatch between the degradation rate and tissue growth, difficulty in vascularization, an inability to address bone defects of various shapes, and risk of infection. To solve these problems, our group designed stereolithography (SLA) 3D-printed calcium silicate artificial bone improved by a calcium sulfate-Cu2+ delivery system. SLA technology endows the scaffold with a three-dimensional tunnel structure to induce cell migration to the center of the bone defect. The calcium sulfate-Cu2+ delivery system was introduced to enhance the osteogenic activity of calcium silicate. Rapid degradation of calcium sulfate (CS) induces early osteogenesis in the three-dimensional tunnel structure. Calcium silicate (CSi) which degrades slowly provides mechanical support and promotes bone formation in bone defect sites for a long time. The gradient degradation of these two components is perfectly matched to the rate of repair in large bone defects. On the other hand, the calcium sulfate delivery system can regularly release Cu2+ in the temporal and spatial dimensions, exerting a long-lasting antimicrobial effect and promoting vascular growth. This powerful 3D-printed calcium silicate artificial bone which has rich osteogenic activity is a promising material for treating large bone defects and has excellent potential for clinical application.

【 授权许可】

Unknown   
Copyright © 2023 Gao, Li, Lei, Chen, Huang, Yan, Xiao, Zhang, Wang, Wei and Hu.