Prevalence and temporal trends of prostate diseases among inpatients with cardiovascular disease: a nationwide real-world database survey in Japan

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Koichi Node¹  Kohei Kaneta¹  Atsushi Tanaka¹  Yoko Sumita²  Michikazu Nakai²  Mitsuru Noguchi³  Hidehiro Kaneko⁴ 

[1] Department of Cardiovascular Medicine, Saga University, Saga, Japan;Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan;Department of Urology, Saga University, Saga, Japan;The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan;The Department of Advanced Cardiology, The University of Tokyo, Tokyo, Japan;

关键词: prostate disease;    benign prostate hyperplasia;    prostate cancer;    cardiovascular disease;    acute coronary syndrome;    heart failure;    epidemiology;    temporal trend;   

DOI  :  10.3389/fcvm.2023.1236144

 received in 2023-06-07, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionBenign prostate hyperplasia (BPH) and prostate cancer (PCa) are major prostate diseases that potentially share cardiometabolic risk factors and an elevated risk for cardiovascular disease (CVD). However, the prevalence of prostate diseases among patients with established CVD remains unclear.Materials and methodsThis nationwide retrospective study assessed the prevalence and temporal trend of prostate diseases (i.e., BPH or PCa) among patients hospitalized for CVDs in Japan. We used a claims database (the Japanese Registry of All Cardiac and Vascular Diseases–Diagnosis Procedure Combination), which included data on 6,078,487 male patients recorded from 1,058 hospitals between April 2012 and March 2020. We conducted the Cochran–Armitage trend test and calculated the adjusted odds ratio (aOR) with 95% confidence intervals (CIs).ResultsThe prevalence of prostate diseases over the entire study period was 5.7% (BPH, 4.4%; PCa, 1.6%). When dividing the overall cohort into age categories (<65, 65–74, and ≥75 years old), the prevalence was 1.1%, 4.7%, and 9.9%, respectively (P for trend <0.05). In addition, the annual prevalence showed a modest increasing trend over time. Patients admitted for heart failure (HF) were significantly associated with a higher incidence of coexisting prostate diseases than those admitted for non-HF causes [aOR 1.02 (95% CI, 1.01–1.03)] or acute coronary syndrome [aOR 1.19 (95% CI, 1.17–1.22)].ConclusionsThe nationwide real-world database revealed that the prevalence of prostate diseases is increasing among patients hospitalized for CVD, particularly HF. Attention to detailed causality and continued surveillance are needed to further clarify the clinical characteristics of prostate diseases among patients with CVD.

【 授权许可】

Unknown   
© 2023 Kaneta, Tanaka, Nakai, Sumita, Kaneko, Noguchi and Node.