Lipid metabolism reprogramming in head and neck cancer

Frontiers in Oncology

Oncology

Jinfeng Liang¹  Yi Huang¹  Lin Li¹  Xue Xiao²  Zhe Zhang²  Limei Li³  Xiaoying Zhou⁴ 

[1] Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China;Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China;Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China;Department of Pediatric Dentistry, College & Hospital of Stomatology, Guangxi Medical University, Nanning, China;Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China;

关键词: lipid metabolism;    reprogramming;    head and neck cancer;    biomarker;    prognosis;   

DOI  :  10.3389/fonc.2023.1271505

 received in 2023-08-02, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Lipid metabolism reprogramming is one of the most prominent metabolic anomalies in cancer, wherein cancer cells undergo dysregulation of lipid metabolism to acquire adequate energy, cell membrane building blocks, as well as signaling molecules essential for cell proliferation, survival, invasion, and metastasis. These adaptations enable cancer cells to effectively respond to challenges posed by the tumor microenvironment, leading to cancer therapy resistance and poor cancer prognosis. Head and neck cancer, ranking as the seventh most prevalent cancer, exhibits numerous abnormalities in lipid metabolism. Nevertheless, the precise role of lipid metabolic rewiring in head and neck cancer remains unclear. In line with the LIPID MAPS Lipid Classification System and cancer risk factors, the present review delves into the dysregulated molecules and pathways participating in the process of lipid uptake, biosynthesis, transportation, and catabolism. We also present an overview of the latest advancements in understanding alterations in lipid metabolism and how they intersect with the carcinogenesis, development, treatment, and prognosis of head and neck cancer. By shedding light on the significance of metabolic therapy, we aspire to improve the overall prognosis and treatment outcomes of head and neck cancer patients.

【 授权许可】

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Copyright © 2023 Liang, Li, Li, Zhou, Zhang, Huang and Xiao