Key players in the regulation of iron homeostasis at the host-pathogen interface

Frontiers in Immunology

Immunology

Inam Ullah¹  Minglin Lang² 

[1] CAS Center for Excellence in Biotic Interactions, College of Life Science, University of Chinese Academy of Sciences, Beijing, China;CAS Center for Excellence in Biotic Interactions, College of Life Science, University of Chinese Academy of Sciences, Beijing, China;College of Life Science, Agricultural University of Hebei, Baoding, China;

关键词: hepatocytes;    nutritional immunity;    pathogens;    siderophores;    transferrin;   

DOI  :  10.3389/fimmu.2023.1279826

 received in 2023-08-18, accepted in 2023-10-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Iron plays a crucial role in the biochemistry and development of nearly all living organisms. Iron starvation of pathogens during infection is a striking feature utilized by a host to quell infection. In mammals and some other animals, iron is essentially obtained from diet and recycled from erythrocytes. Free iron is cytotoxic and is readily available to invading pathogens. During infection, most pathogens utilize host iron for their survival. Therefore, to ensure limited free iron, the host’s natural system denies this metal in a process termed nutritional immunity. In this fierce battle for iron, hosts win over some pathogens, but others have evolved mechanisms to overdrive the host barriers. Production of siderophores, heme iron thievery, and direct binding of transferrin and lactoferrin to bacterial receptors are some of the pathogens’ successful strategies which are highlighted in this review. The intricate interplay between hosts and pathogens in iron alteration systems is crucial for understanding host defense mechanisms and pathogen virulence. This review aims to elucidate the current understanding of host and pathogen iron alteration systems and propose future research directions to enhance our knowledge in this field.

【 授权许可】

Unknown   
Copyright © 2023 Ullah and Lang