Bromoform exposure is associated with non-melanoma skin cancer: evidence from NHANES 2011–2020

Frontiers in Public Health

Public Health

Jingjing Han¹  Yinglong Hou¹  Zimao Wang¹  Zheng Yang¹  Mingnan Gao¹  Han Guo¹  Jinhua Liu¹  Qiying Wang² 

[1] Department of Plastic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China;null;

关键词: trihalomethanes;    bromoform;    non-melanoma skin cancer;    water;    swimming;    cancer prevention;   

DOI  :  10.3389/fpubh.2023.1191881

 received in 2023-03-22, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundNon-melanoma skin cancer (NMSC) is a prevalent skin malignancy. It has been indicated in many studies that trihalomethanes (THMs) exposure has a strong association with tumors but has not been associated with NMSC. Our investigation aims to explore the association between THMs exposure and NMSC.MethodsCross-sectional data from the 2011 to 2020 National Health and Nutrition Examination Survey (NHANES) was collected. Poisson regression and subgroup analyses were performed to evaluate the association between individual THMs components and NMSC. Fitted smoothing curves and generalized additive models were also used.ResultsThis study involved 5,715 individuals, 98 (1.7%) of whom self-reported NMSC. After adjusting for covariates, Poisson regression showed that higher blood TBM levels were associated with an increased likelihood of NMSC (OR = 1.03; 95% CI: 1.01–1.05, p = 0.002). However, the correlation between the blood levels of TCM, DBCM, and BDCM and the likelihood of NMSC was not statistically significant (all p > 0.05). Subgroup analysis and interaction tests showed no significant differences between blood TBM concentration and the likelihood of NMSC, indicating that age, gender, and race were significantly independent of this positive association (all p < 0.05).ConclusionsOur results implied that among adults older than 65 years old in the U.S., elevated blood TBM concentrations were positively associated with NMSC. More prospective investigations are required to validate this relationship with the early prevention of NMSC.

【 授权许可】

Unknown   
Copyright © 2023 Gao, Guo, Han, Liu, Hou, Wang, Yang and Wang.