Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes

Frontiers in Oncology

Oncology

Samantha Hettige¹  Joanna Stone²  Sucheta J. Vaidya²  Assunta Albanese³  Julia V. Cockle⁴  Paola Angelini⁴  Henry C. Mandeville⁵  Fernando Carceller⁶  Lynley V. Marshall⁶  Bassel Zebian⁷  R Jane Leitch⁸  Elizabeth A. Corley⁹ 

[1] Atkinson Morley Neurosurgery Centre, St George’s University Hospital National Health Service (NHS) Foundation Trust, London, United Kingdom;Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;Department of Pediatric Endocrinology, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom;Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom;Department of Radiotherapy, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom;Pediatric and Adolescent Oncology Drug Development Team, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;Department of Neurosurgery, Kings College Hospital National Health Service (NHS) Trust, London, United Kingdom;Department of Ophthalmology, Epsom and St Hellier University Hospitals Trust, Carshalton, United Kingdom;Pediatric and Adolescent Oncology Drug Development Team, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom;

关键词: pediatric diencephalic tumors;    glioma;    craniopharyngioma;    germ cell tumor;    Langerhans cell histiocytosis;    molecularly targeted therapies;    functional outcomes;   

DOI  :  10.3389/fonc.2023.1178553

 received in 2023-03-02, accepted in 2023-07-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Pediatric diencephalic tumors represent a histopathologically and molecularly diverse group of neoplasms arising in the central part of the brain and involving eloquent structures, including the hypothalamic-pituitary axis (HPA), optic pathway, thalamus, and pineal gland. Presenting symptoms can include significant neurological, endocrine, or visual manifestations which may be exacerbated by injudicious intervention. Upfront multidisciplinary assessment and coordinated management is crucial from the outset to ensure best short- and long-term functional outcomes. In this review we discuss the clinical and pathological features of the neoplastic entities arising in this location, and their management. We emphasize a clear move towards ‘function preserving’ diagnostic and therapeutic approaches with novel toxicity-sparing strategies, including targeted therapies.

【 授权许可】

Unknown   
Copyright © 2023 Cockle, Corley, Zebian, Hettige, Vaidya, Angelini, Stone, Leitch, Albanese, Mandeville, Carceller and Marshall