Revolutionizing cancer treatment: nanotechnology-enabled photodynamic therapy and immunotherapy with advanced photosensitizers

Frontiers in Immunology

Immunology

Xue Wu¹  Gongwei Long²  Dongwen Wang²  Jiedong Jia²  Jun Tian³  Zhangqun Ye⁴  Wei He⁴  Huiping Zhang⁵  Jie Yu⁶ 

[1] Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China;Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China;Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China;Department of Urology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical, Beijing, China;Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, China;

关键词: nanotechnology;    photodynamic therapy;    immunotherapy;    photosensitizers;    cancer treatment;    photosensitizer;   

DOI  :  10.3389/fimmu.2023.1219785

 received in 2023-05-09, accepted in 2023-09-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Nanotechnology-enhanced photodynamic therapy (PDT) and immunotherapy are emerging as exciting cancer therapeutic methods with significant potential for improving patient outcomes. By combining these approaches, synergistic effects have been observed in preclinical studies, resulting in enhanced immune responses to cancer and the capacity to conquer the immunosuppressive tumor microenvironment (TME). Despite challenges such as addressing treatment limitations and developing personalized cancer treatment strategies, the integration of nanotechnology-enabled PDT and immunotherapy, along with advanced photosensitizers (PSs), represents an exciting new avenue in cancer treatment. Continued research, development, and collaboration among researchers, clinicians, and regulatory agencies are crucial for further advancements and the successful implementation of these promising therapies, ultimately benefiting cancer patients worldwide.

【 授权许可】

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Copyright © 2023 Jia, Wu, Long, Yu, He, Zhang, Wang, Ye and Tian