Genetic background influences pig responses to porcine reproductive and respiratory syndrome virus

Frontiers in Veterinary Science

Veterinary Science

Yangli Pei¹  Chenghong Lin¹  Hua Li¹  Zheng Feng² 

[1] Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Key Laboratory of Animal Molecular Design and Precise Breeding of Guangdong Higher Education Institutes, School of Life Science and Engineering, Foshan University, Foshan, China;null;

关键词: porcine reproductive and respiratory syndrome;    pig breeds;    genetic backgrounds;    PRRSV;    PRRSV receptors;    innate immunity;    acquired immunity;   

DOI  :  10.3389/fvets.2023.1289570

 received in 2023-09-06, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious and economically significant virus that causes respiratory and reproductive diseases in pigs. It results in reduced productivity and increased mortality in pigs, causing substantial economic losses in the industry. Understanding the factors affecting pig responses to PRRSV is crucial to develop effective control strategies. Genetic background has emerged as a significant determinant of susceptibility and resistance to PRRSV in pigs. This review provides an overview of the basic infection process of PRRSV in pigs, associated symptoms, underlying immune mechanisms, and roles of noncoding RNA and alternative splicing in PRRSV infection. Moreover, it emphasized breed-specific variations in these aspects that may have implications for individual treatment options.

【 授权许可】

Unknown   
Copyright © 2023 Pei, Lin, Li and Feng.