Is the long-term mortality similar in COVID-19 and community-acquired pneumonia?

Frontiers in Medicine

Medicine

Antoni Torres¹  David Hervás²  Catia Cillóniz³  Rafael Zalacain⁴  Luis A. Ruiz⁵  Leyre Serrano⁵  Pedro P. España⁶  Noé Mengot⁷  Rosario Menéndez⁸  Paula González-Jiménez⁹  Francisca Lerenas Bernal^1,11  Irene Cano^1,11  Ana Latorre^1,11  José Portillo Sánchez^1,11  Aurelio Luis Wangüemert Pérez^1,11  Noelia Fernández Ramos^1,11  Jaume Bordas^1,11  Marco Francisco Pereyra Barrionuevo^1,11  Adrián Baeza Ruiz^1,11  Luis Molinos^1,11  Sara Guanche Dorta^1,11  Graciliano Estrada Trigueros^1,11  José M. Cifrián Martínez^1,11  Selene Cuenca Peris^1,11  María Estela González Castro^1,11  Rocío García García^1,11  Diana Badenes Bonet^1,11  Miguel Torres García^1,11  Tara Pereiro Brea^1,11  Inés Podzamczer Valls^1,11  Ester Rodríguez Florez^1,11  Gianna Vargas Centanaro^1,11  Eva Cabrera César^1,11  Miguel Ángel Salvador Maya^1,11  Iván Arroyo Fernández^1,11  Laura Moreno Galarraga^1,11  José Joel Ruiz Lacambra^1,11  Nuria Gutiérrez González^1,11  Pilar Cejudo Ramos^1,11  Jordi Almirall^1,11  Montserrat Vendrell^1,11  María José^1,11  Virginia Guevara Velázquez^1,11  Blanca de Vega Sánchez^1,11  Elizabeth de Freitas González^1,11  Paula González^1,11  Iria Pérez Orbis^1,11  Paloma Clavería^1,11  Chourio Estaba^1,11  Alba Esperanza Barrios^1,11  Pilar Muñoz Zara^1,11  Teresa Ramírez Prieto^1,11  José Alfonso García Guerra^1,11  Beatriz Raboso Moreno^1,11  Javier Lázaro Sierra^1,11  Ferran Eduard Barbé Illa^1,11  Concepción Morales^1,11  Itxaso Sayago Reza^1,11  Marisol Domínguez Álvarez^1,11  Rosario Menéndez Villanueva^1,11  María Salome Ros Braquehais^1,11  Marta María García Clemente^1,11  Carolina Gotera Rivera^1,11  Esther Palones Femenia^1,11  Carolina Panadero^1,11  Olga Rajas^1,11  Estela García Coya^1,11  Alejandra Marín Arguedas^1,11  Luisa Ramón Clar^1,11  David de la Rosa Carrillo^1,11  María del Mar Marrube Fernández^1,11  Rosa Malo^1,11  Manuel Villanueva Montes^1,11  MªLuisa Briones^1,11  Andrea Expósito Marrero^1,11  Marina Galdeano Lozano^1,11  Oriol Sibila Vidal^1,11  María Molina Molina^1,11  Luis Borderías^1,11  Araceli Abad^1,11  Berta Román Bernal^1,11  Santiago de Jorge Domínguez Pazos,^1,11  Abigail Macias Paredes^1,11  Juan Marco Figueira Gonçalves^1,11  María Dolores Martínez Pitarch^1,11  Juan Luis Rodríguez Hermosa^1,11  Celia Ruiz Pérez^1,11  Amelia Alzueta Álvarez^1,11  Eduardo Solís García^1,11  Mirella Gaboli^1,11  Salvador Bello^1,11  Pedro Pablo España Yandiola^1,11  Laura Villar Aguilar^1,11  Anna Clara^1,11  Ricard Ferrer^1,11  Wanda Almonte Batista^1,11  Rosa Malo de Molina Ruiz^1,11  Patricia Peñacoba Toribio^1,11  Cecilia López Ramírez^1,11  Pilar Martínez Olondris^1,11  Raúl Méndez^1,11  Eli N. Pérez-Rodas^1,11  Nuria Toledo Pons^1,11  Margarita Martín Royo^1,11  Ana Pando-Sandoval^1,11  Nikita Gurbani^1,11  Rafael Zalacaín^1,11  Virginia Almadana Pacheco^1,11  Claudia Valenzuela^1,11  Isabel Mir^1,11  Pedro Pablo España^1,11  Ane Uranga^1,11 

[1] Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain;Department of Medicine, University of Barcelona, Barcelona, Spain;August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain;Pneumology Department, Hospital Clinic of Barcelona, Barcelona, Spain;Data Science, Biostatistics and Bioinformatics, Health Research Institute La Fe (IISLAFE), Valencia, Spain;Department of Applied Statistics and Operational Research and Quality, Universitat Politècnica de València, Valencia, Spain;Department of Medicine, University of Barcelona, Barcelona, Spain;Faculty of Health Sciences, Continental University, Huancayo, Peru;August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain;Pneumology Department, Cruces University Hospital, Barakaldo, Spain;Pneumology Department, Cruces University Hospital, Barakaldo, Spain;Department of Immunology, Microbiology and Parasitology, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU, Leioa, Spain;Pneumology Department, Galdakao-Usansolo Hospital, Galdacano, Spain;Pneumology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;Respiratory Infections, Health Research Institute La Fe (IISLAFE), Valencia, Spain;Pneumology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;Respiratory Infections, Health Research Institute La Fe (IISLAFE), Valencia, Spain;Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain;Department of Medicine, University of Valencia, Valencia, Spain;Pneumology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;Respiratory Infections, Health Research Institute La Fe (IISLAFE), Valencia, Spain;Department of Medicine, University of Valencia, Valencia, Spain;Respiratory Infections, Health Research Institute La Fe (IISLAFE), Valencia, Spain;null;

关键词: long-term;    mortality;    COVID-19;    pneumonia;    Bayesian;   

DOI  :  10.3389/fmed.2023.1236142

 received in 2023-06-07, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThere are no data on the association of type of pneumonia and long-term mortality by the type of pneumonia (COVID-19 or community-acquired pneumonia [CAP]) on long-term mortality after an adjustment for potential confounding variables. We aimed to assess the type of pneumonia and risk factors for long-term mortality in patients who were hospitalized in conventional ward and later discharged.MethodsRetrospective analysis of two prospective and multicentre cohorts of hospitalized patients with COVID-19 and CAP. The main outcome under study was 1-year mortality in hospitalized patients in conventional ward and later discharged. We adjusted a Bayesian logistic regression model to assess associations between the type of pneumonia and 1-year mortality controlling for confounders.ResultsThe study included a total of 1,693 and 2,374 discharged patients in the COVID-19 and CAP cohorts, respectively. Of these, 1,525 (90.1%) and 2,249 (95%) patients underwent analysis. Until 1-year follow-up, 69 (4.5%) and 148 (6.6%) patients from the COVID-19 and CAP cohorts, respectively, died (p = 0.008). However, the Bayesian model showed a low probability of effect (PE) of finding relevant differences in long-term mortality between CAP and COVID-19 (odds ratio 1.127, 95% credibility interval 0.862–1.591; PE = 0.774).ConclusionCOVID-19 and CAP have similar long-term mortality after adjusting for potential confounders.

【 授权许可】

Unknown   
Copyright © 2023 Méndez, González-Jiménez, Latorre, Mengot, Zalacain, Ruiz, Serrano, España, Uranga, Cillóniz, Hervás, Torres, Menéndez, NEUMONAC and RECOVID.