NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects

Frontiers in Dental Medicine

Dental Medicine

Maria L. Geisinger¹ 

[1] Correspondence:;

关键词: periodontal regeneration;    periodontitis;    wound healing;    regenerative medicine;    growth factors;    signaling molecules;   

DOI  :  10.3389/fdmed.2023.1239149

 received in 2023-06-12, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Regeneration of periodontal tissues that have been destroyed by inflammatory periodontitis involves the initiation of tissue engineering and wound healing of multiple tissues involved in the function of the teeth, including the periodontal ligament, cementum, and alveolar bone. Such regeneration is termed guided tissue regeneration and the unique challenges to reconstruct these tissues involves a complex interplay of cells, signaling molecules, and scaffolds. While traditional guided tissue regeneration treatments have involved cell occlusive membranes, bone replacement graft scaffolds, and endogenous multipotent mesenchymal stem cells, the use of adjunctive materials to enhance healing outcomes has been studied and many such adjunctive factors are in common current clinical use. This report will focus on the current and emerging adjunctive growth factors and signaling molecules that can be used to optimize periodontal regeneration in periodontal intrabony defects, their mechanisms of action, the challenges associated with periodontal regeneration, and future avenues for research.

【 授权许可】

Unknown   
© 2023 Geisinger.