Prognostic risk of immune-associated signature in the microenvironment of brain gliomas

Frontiers in Genetics

Genetics

Xiaoling Yu¹  Huaiwei Cong¹  Jinpeng Li¹  Qian Chen²  Yaling Tao³  Ting Cai³  Junqi Zhu⁴ 

[1] Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China;Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China;Thorgene Co., Ltd., Beijing, China;Ningbo Hangzhou Bay Hospital, Ningbo, China;Ningbo No 2 Hospital, Ningbo, China;Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China;Thorgene Co., Ltd., Beijing, China;

关键词: brain glioma;    prognosis;    risk score;    immune-related genes;    immune cells;    tumor microenvironment;   

DOI  :  10.3389/fgene.2023.1208651

 received in 2023-04-19, accepted in 2023-09-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

Understanding the key factors in the tumor microenvironment (TME) that affect the prognosis of gliomas is crucial. In this study, we sought to uncover the prognostic significance of immune cells and immune-related genes in the TME of gliomas. We incorporated data of 970 glioma patient samples from the Chinese Glioma Genome Atlas (CGGA) database as the training set, and an additional set of 666 samples from The Cancer Genome Atlas (TCGA) database served as the validation set. From our analysis, we identified 21 immune-related differentially expressed genes (DEGs) in the TME, which holds implications for glioma prognosis. Based on these genes, we constructed a prognostic risk model on the 21 genes. The prognostic risk model demonstrated robust performance with an area under the curve (AUC) value of 0.848. Notably, the risk score derived from the model emerged as an independent prognostic factor of gliomas, with high risk scores indicative of an unfavorable prognosis. Furthermore, we observed that high infiltration levels of certain immune cells, namely, activated dendritic cells, M0 macrophages, M2 macrophages, and regulatory T cells (Tregs), correlated with an unfavorable glioma prognosis. In conclusion, our findings suggested that the TME of gliomas harbored a distinct immune-associated signature, comprising 21 immune-related genes and specific immune cells. These elements significantly influence the prognosis and present potential as novel indicators in the clinical assessment of glioma patient outcomes.

【 授权许可】

Unknown   
Copyright © 2023 Tao, Zhu, Yu, Cong, Li, Cai and Chen.