Altered local and remote functional connectivity in mild Alzheimer’s disease patients with sleep disturbances

Frontiers in Aging Neuroscience

Aging Neuroscience

Lei Wang¹  Zhiyong Zhang¹  Rui Zhu¹  Dantao Peng²  Xiao Zhou³ 

[1] Department of Neurology, Beijing Geriatric Hospital, Beijing, China;Department of Neurology, China-Japan Friendship Hospital, Beijing, China;Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, China;

关键词: Alzheimer’s disease;    sleep disturbances;    rs-fMRI;    functional connectivity;    ReHo;   

DOI  :  10.3389/fnagi.2023.1269582

 received in 2023-07-30, accepted in 2023-10-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesThis study aimed to investigate local and remote functional connectivity in mild Alzheimer’s disease patients with sleep disturbances (ADSD) and those without sleep disturbances (ADNSD).MethodsThirty eight mild AD patients with sleep disturbances and 21 mild AD patients without sleep disturbances participated in this study. All subjects underwent neuropsychological assessments and 3.0 Tesla magnetic resonance scanning. Static and dynamic regional homogeneity (ReHo) were used to represent the local functional connectivity. Seed-based whole-brain functional connectivity was used to represent the remote functional connectivity. The seed was chosen based on the results of ReHo.ResultsCompared to ADNSD, ADSD showed decreased static ReHo in the left posterior central gyrus and the right cuneus and increased dynamic ReHo in the left posterior central gyrus. As for the remote functional connectivity, comparing ADSD to ADNSD, it was found that there was a decreased functional connection between the left posterior central gyrus and the left cuneus as well as the left calcarine.ConclusionThe current study demonstrated that, compared with ADNSD, ADSD is impaired in both local and remote functional connectivity, manifested as reduced functional connectivity involving the primary sensory network and the primary visual network. The abnormality of the above functional connectivity is one of the reasons why sleep disorders promote cognitive impairment in AD. Moreover, sleep disorders change the temporal sequence of AD pathological damage to brain functional networks, but more evidence is needed to support this conclusion.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Zhu, Zhou, Zhang and Peng.