Inhaled nitric oxide: can it serve as a savior for COVID-19 and related respiratory and cardiovascular diseases?

Frontiers in Microbiology

Microbiology

Jiayu Cheng¹  Yifan Zhao¹  Yonggang Wang¹  Cheng Li¹  Shuai Zhang¹  Yinghui Wang¹  Yucheng Liu²  Xiaorong Han³ 

[1] Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, China;Department of Family and Community Medicine, Feinberg School of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, United States;Department of Special Care Center, Fuwai Hospital, National Clinical Research Center for Cardiovascular Diseases, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China;

关键词: nitric oxide;    inhaled nitric oxide;    COVID-19;    pulmonary arterial hypertension;    lung infection;    acute respiratory distress syndrome;   

DOI  :  10.3389/fmicb.2023.1277552

 received in 2023-08-14, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Nitric oxide (NO), as an important gaseous medium, plays a pivotal role in the human body, such as maintaining vascular homeostasis, regulating immune-inflammatory responses, inhibiting platelet aggregation, and inhibiting leukocyte adhesion. In recent years, the rapid prevalence of coronavirus disease 2019 (COVID-19) has greatly affected the daily lives and physical and mental health of people all over the world, and the therapeutic efficacy and resuscitation strategies for critically ill patients need to be further improved and perfected. Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator, and some studies have demonstrated its potential therapeutic use for COVID-19, severe respiratory distress syndrome, pulmonary infections, and pulmonary hypertension. In this article, we describe the biochemistry and basic characteristics of NO and discuss whether iNO can act as a “savior” for COVID-19 and related respiratory and cardiovascular disorders to exert a potent clinical protective effect.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Li, Zhang, Cheng, Liu, Han, Wang and Wang.