Prevalence and risk factors for high-risk human papillomavirus infection among women from three southern geopolitical zones of Nigeria

Frontiers in Oncology

Oncology

Ning Feng¹  Xiao−ping Dong¹  Leona Chika Okoli²  Olaoniye Habeebat Labo−Popoola²  Chika Kingsley Onwuamah²  Chinenye Angela Ogbu²  Grace Deborah Vincent²  Abidemi Esther Momoh²  Temiloluwa Ojopagogo²  Mary Adesina²  Mabel Uwandu²  Omowunmi Sowunmi²  Joseph Ojonugwa Shaibu²  Bowofoluwa Sharon Abimbola²  Judith Sokei³  Rahaman Ademolu Ahmed⁴  Agatha David⁵  Oliver Chukwujekwu Ezechi⁵  Greg Aigbe Ohihoin⁵  Ifeoma Idigbe⁵  Jane Okwuzu⁵  Priscilla Ngozi Ezemelue⁵  Nkem Okonkwo⁶  Emily Nzeribe⁷  Ighovwerha Ofotokun⁸  Olufemi Olaleye⁹ 

[1] Center for Global Public Health, Chinese Centre for Disease Control and Prevention, Beijing, China;Centre for Human Virology and Genomics, Department of Microbiology, Nigerian Institute of Medical Research, Lagos, Nigeria;Centre for Human Virology and Genomics, Department of Microbiology, Nigerian Institute of Medical Research, Lagos, Nigeria;Department of Pediatric Oncology (Hematology), Washington University in St. Louis, St. Louis, MO, United States;Centre for Human Virology and Genomics, Department of Microbiology, Nigerian Institute of Medical Research, Lagos, Nigeria;Division of Allergy and Clinical Immunology, Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States;Centre for Reproduction and Population Health Studies, Department of Clinical Sciences, Nigeria Institute Medical Research, Lagos, Nigeria;Department of Obstetrics and Gynaecology, Delta State University Teaching Hospital, Oghara, Delta, Nigeria;Department of Obstetrics and Gynaecology, Federal Medical Centre, Owerri, Imo, Nigeria;Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States;Screening Section, Optimal Cancer Care Foundation Centre, Lagos, Nigeria;

关键词: HPV;    risk factor;    women;    Nigeria;    cervical cancer;   

DOI  :  10.3389/fonc.2023.1254304

 received in 2023-07-06, accepted in 2023-09-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionHuman Papillomavirus (HPV) infection is a risk factor for cervical cancer, the fourth most common cancer among women globally. Its burden is the highest in sub-Saharan Africa, with over 90% mortality. Interventions may fail without evidence-based data on stratified prevalence and risk factors among most at-risk women across Nigeria.MethodsA cross-sectional comparative study, with participants recruited from the Nigerian Institute of Medical Research’s Clinics, NGO outreaches, a cancer screening centre and a university teaching hospital. Questionnaires were self-administered. Trained medics performed sampling at healthcare facilities, and self-sampling was used at outreaches.ResultsNine hundred eighty-five study participants were recruited. About 37% and 27% of the women knew about HPV and its vaccines, respectively, but only 6% confirmed vaccination with HPV vaccines. HPV prevalence was highest among women with unknown marital status (35.9%), single women (33.8%), widowed/divorced/separated women (30.3%), and married/cohabiting women (19.6%). HPV infection was significantly higher among women who take alcohol (odds=1.7 [95% CI: 1.2-2.4]) and women who smoke (odds=2.6 [95% CI: 1.4 - 4.6]. HPV strains detected included HPV16 (1.3%), HPV18 (1.5%), Low Risk (0.2%) and Other High-Risk groups (19.7%).ConclusionThe inverse relationship between prevalence and education suggests interventions improving awareness and prevention would be impactful. Such interventions could also target HIV-positive women, women presenting with sexually-transmitted infections, who smoke and frequently drink alcohol.

【 授权许可】

Unknown   
Copyright © 2023 Onwuamah, Feng, Momoh, Uwandu, Ahmed, Idigbe, Vincent, Ogbu, Okonkwo, Sokei, Abimbola, Ojopagogo, Okoli, Adesina, Ezemelue, Sowunmi, Okwuzu, Labo−Popoola, Shaibu, Ohihoin, Nzeribe, David, Olaleye, Ofotokun, Dong and Ezechi