Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease

Frontiers in Chemical Engineering

Chemical Engineering

Ziming Shao¹  Federica Michielin¹  Paolo De Coppi² 

[1] Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom;Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom;Great Ormond Street Hospital (GOSH), London, United Kingdom;

关键词: lung organoids;    mechanobiology;    biophysical cues;    lung distal diseases;    disease modelling;   

DOI  :  10.3389/fceng.2023.1255783

 received in 2023-07-09, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Lung organoids have emerged as powerful tools for studying lung distal diseases by recapitulating the cellular diversity and microenvironment of the lung tissue. This review article highlights the advancements in leveraging mechanobiology and biophysical cues in lung organoid engineering to improve their physiological relevance and disease modelling capabilities. We discuss the role of mechanobiology in lung development and homeostasis, as well as the integration of biophysical cues in the design and culture of lung organoids. Furthermore, we explore how these advancements have contributed to the understanding of lung distal diseases pathogenesis. We also discuss the challenges and future directions in harnessing mechanobiology and biophysical cues in lung organoid research. This review showcases the potential of lung organoids as a platform to investigate the underappreciated impacts of biophysical and biomechanical properties in enhancing lung organoids complexity and functionality, and ultimately provide new insight into embryonic lung development and pulmonary distal diseases pathogenesis.

【 授权许可】

Unknown   
Copyright © 2023 Shao, De Coppi and Michielin.