Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations

Frontiers in Nutrition

Nutrition

Laura L. Bauer¹  Sharon M. Donovan²  Loretta T. Sutkus³  Rebecca K. Golden³  Ryan N. Dilger⁴ 

[1] Department of Animal Sciences, University of Illinois, Urbana, IL, United States;Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL, United States;Division of Nutritional Sciences, University of Illinois, Urbana, IL, United States;Neuroscience Program, University of Illinois, Urbana, IL, United States;Neuroscience Program, University of Illinois, Urbana, IL, United States;Department of Animal Sciences, University of Illinois, Urbana, IL, United States;Division of Nutritional Sciences, University of Illinois, Urbana, IL, United States;

关键词: growth;    hematology;    histomorphology;    sialic acid;    3ˊ-sialyllactose;    6ˊ-sialyllactose;   

DOI  :  10.3389/fnut.2023.1278804

 received in 2023-08-16, accepted in 2023-09-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Sialylated oligosaccharides, including 3ˊ-sialyllactose (3ˊ-SL) and 6ˊ-sialyllactose (6ˊ-SL), comprise a large portion of human milk and have been known to support development over the first year of life. While research has investigated the impact of early-life supplementation, longer-term supplementation remains relatively unexplored. Consequently, the following study assesses the impact of supplementation of either 3ˊ-SL or 6ˊ-SL on growth performance, tolerance, and brain sialic acid concentrations. Two-day-old piglets (n = 75) were randomly assigned to a commercial milk replacer ad libitum without or with 3ˊ-SL or 6ˊ-SL (added at 0.2673% on an as-is basis). Daily body weight and feed disappearance were recorded to assess growth performance and tolerance. Pigs were euthanized for sample collection on postnatal day 33 (n = 30) or 61 (n = 33), respectively. Across growth performance, clinical chemistry and hematology, histomorphology, and sialic acid quantification, dietary differences were largely unremarkable at either time-point. Overall, SA was well-tolerated both short-term and long-term.

【 授权许可】

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Copyright © 2023 Golden, Sutkus, Bauer, Donovan and Dilger.