Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report

Frontiers in Oncology

Oncology

Xiang Yan¹  Chen Chen¹  Ouyang Yingyao¹  Wang Hong¹  Yang Lei¹  He Qianru² 

[1] Department of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China;The Medical Department, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing, China;Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China;The State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing, China;

关键词: cutaneous metastases;    neoplasm metastasis;    ovarian cancer;    skin metastases;    treatment;   

DOI  :  10.3389/fonc.2023.1266820

 received in 2023-07-25, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cutaneous metastases of ovarian cancer are rare and often have poor prognosis. We report a case of a 62-year-old woman with recurrent low-grade serous ovarian cancer, who presented with lung, brain, and multiple skin (nasal and anterior chest wall) metastases approximately six months after the initial diagnosis. In this case, Nijmegen breakage syndrome carrier status caused by RAD50 heterozygous mutation and previous bevacizumab therapy could be the predisposing factor for cutaneous metastases. The patient was treated with local radiotherapy (nasal skin and brain, 30Gy/6f/1.2W) and three courses of chemotherapy with albumin-bound paclitaxel and carboplatin, resulting in drastic remission of the cutaneous metastases. Unfortunately, treatment interruption resulted in rapid tumor progression, followed by death. This case represents an interesting example of cutaneous metastasis of ovarian cancer with rare clinical manifestations, unique genetic mutations, and reasonable response to treatment. Chemoradiotherapy might be an appropriate option for cutaneous metastases of ovarian cancer. Nevertheless, we still hope to find out the best treatment strategy after collecting and reviewing more cases in the future.

【 授权许可】

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Copyright © 2023 Chen, Yingyao, Yan, Qianru, Hong, Chen and Lei