Frontiers in Veterinary Science | |
Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs | |
Veterinary Science | |
Yoonhoi Koo1  Yeon Chae2  Taesik Yun2  Mhan-Pyo Yang2  Dohee Lee2  Hakhyun Kim2  Byeong-Teck Kang2  | |
[1] College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea;Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea; | |
关键词: biomarker; canine; hypoxemia; ischemia; NfL; | |
DOI : 10.3389/fvets.2023.1284306 | |
received in 2023-08-28, accepted in 2023-10-02, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.
【 授权许可】
Unknown
Copyright © 2023 Yun, Chae, Koo, Lee, Kim, Yang and Kang.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202311146247560ZK.pdf | 266KB | download |