Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs

Frontiers in Veterinary Science

Veterinary Science

Yoonhoi Koo¹  Yeon Chae²  Taesik Yun²  Mhan-Pyo Yang²  Dohee Lee²  Hakhyun Kim²  Byeong-Teck Kang² 

[1] College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea;Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea;

关键词: biomarker;    canine;    hypoxemia;    ischemia;    NfL;   

DOI  :  10.3389/fvets.2023.1284306

 received in 2023-08-28, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.

【 授权许可】

Unknown   
Copyright © 2023 Yun, Chae, Koo, Lee, Kim, Yang and Kang.