Comparative pathology of experimental pulmonary tuberculosis in animal models

Frontiers in Veterinary Science

Veterinary Science

Francisco J. Salguero¹  Emma Rayner¹  Inés Ruedas-Torres²  Irene Agulló-Ros²  Laura Hunter³ 

[1]Pathology Department, UK Health Security Agency (UKHSA), Porton Down, Salisbury, United Kingdom

[2]Pathology Department, UK Health Security Agency (UKHSA), Porton Down, Salisbury, United Kingdom

[3]Department of Anatomy and Comparative Pathology and Toxicology, UIC Zoonosis y Enfermedades Emergentes ENZOEM, University of Córdoba, International Excellence Agrifood Campus, Córdoba, Spain

[4]Pathology Department, UK Health Security Agency (UKHSA), Porton Down, Salisbury, United Kingdom

[5]School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom

关键词: tuberculosis;    animal models;    pathology;    granuloma;    mycobacteria;    lung;   

DOI  :  10.3389/fvets.2023.1264833

 received in 2023-07-21, accepted in 2023-09-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

Research in human tuberculosis (TB) is limited by the availability of human tissues from patients, which is often altered by therapy and treatment. Thus, the use of animal models is a key tool in increasing our understanding of the pathogenesis, disease progression and preclinical evaluation of new therapies and vaccines. The granuloma is the hallmark lesion of pulmonary tuberculosis, regardless of the species or animal model used. Although animal models may not fully replicate all the histopathological characteristics observed in natural, human TB disease, each one brings its own attributes which enable researchers to answer specific questions regarding TB immunopathogenesis. This review delves into the pulmonary pathology induced by Mycobacterium tuberculosis complex (MTBC) bacteria in different animal models (non-human primates, rodents, guinea pigs, rabbits, cattle, goats, and others) and compares how they relate to the pulmonary disease described in humans. Although the described models have demonstrated some histopathological features in common with human pulmonary TB, these data should be considered carefully in the context of this disease. Further research is necessary to establish the most appropriate model for the study of TB, and to carry out a standard characterisation and score of pulmonary lesions.

【 授权许可】

Unknown   
Copyright © 2023 Hunter, Ruedas-Torres, Agulló-Ros, Rayner and Salguero.