The role of inflammation in autoimmune disease: a therapeutic target

Frontiers in Immunology

Immunology

Qian Su¹  Yu Xiang²  Jianyou Shi²  Die Jiang³  Mingxue Zhang⁴ 

[1] Department of Health Management & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China;Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China;School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China;State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China;

关键词: autoimmunity;    inflammation;    pro-inflammatory factors;    T cells;    B cells;   

DOI  :  10.3389/fimmu.2023.1267091

 received in 2023-07-26, accepted in 2023-09-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are increasing year by year. AIDs are produced by the immune system’s misidentification of self-antigens, seemingly caused by excessive immune function, but in fact they are the result of reduced accuracy due to the decline in immune system function, which cannot clearly identify foreign invaders and self-antigens, thus issuing false attacks, and eventually leading to disease. The occurrence of AIDs is often accompanied by the emergence of inflammation, and inflammatory mediators (inflammatory factors, inflammasomes) play an important role in the pathogenesis of AIDs, which mediate the immune process by affecting innate cells (such as macrophages) and adaptive cells (such as T and B cells), and ultimately promote the occurrence of autoimmune responses, so targeting inflammatory mediators/pathways is one of emerging the treatment strategies of AIDs. This review will briefly describe the role of inflammation in the pathogenesis of different AIDs, and give a rough introduction to inhibitors targeting inflammatory factors, hoping to have reference significance for subsequent treatment options for AIDs.

【 授权许可】

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Copyright © 2023 Xiang, Zhang, Jiang, Su and Shi