Dyslipidemia in rheumatoid arthritis: the possible mechanisms

Frontiers in Immunology

Immunology

Sisi Yang¹  Weiji Lin²  Liang Han²  Yao Huang²  Zhe Chen²  Ruiyuan Zhang²  Jiahui Yan²  Xin Ba²  Ying Huang²  Kai Qin²  Shenghao Tu²  Yu Wang²  Tingting Li²  Pan Shen³ 

[1] Department of Geriatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China;Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China;Department of Rheumatology and Immunology, Zhongnan Hospital of Wuhan University, Wuhan, China;

关键词: dyslipidemia;    rheumatoid arthritis;    cardiovascular disease;    high-density lipoprotein cholesterol;    low-density lipoprotein cholesterol;    mechanism;   

DOI  :  10.3389/fimmu.2023.1254753

 received in 2023-07-07, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, of which the leading cause of death is cardiovascular disease (CVD). The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) in RA decrease especially under hyperinflammatory conditions. It is conflictive with the increased risk of CVD in RA, which is called “lipid paradox”. The systemic inflammation may explain this apparent contradiction. The increased systemic proinflammatory cytokines in RA mainly include interleukin-6(IL-6)、interleukin-1(IL-1)and tumor necrosis factor alpha(TNF-α). The inflammation of RA cause changes in the subcomponents and structure of HDL particles, leading to a weakened anti-atherosclerosis function and promoting LDL oxidation and plaque formation. Dysfunctional HDL can further worsen the abnormalities of LDL metabolism, increasing the risk of cardiovascular disease. However, the specific mechanisms underlying lipid changes in RA and increased CVD risk remain unclear. Therefore, this article comprehensively integrates the latest existing literature to describe the unique lipid profile of RA, explore the mechanisms of lipid changes, and investigate the impact of lipid changes on cardiovascular disease.

【 授权许可】

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Copyright © 2023 Yan, Yang, Han, Ba, Shen, Lin, Li, Zhang, Huang, Huang, Qin, Wang, Tu and Chen