Sestrin2 in diabetes and diabetic complications

Frontiers in Endocrinology

Endocrinology

Xiaodan Zhang¹  Yu Li¹  Wangen Li¹  Zirui Luo²  Jiahong Li²  Yaxuan Lin² 

[1] Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;The Second Clinical Medicine School, Guangzhou Medical University, Guangzhou, China;

关键词: diabetes;    diabetic complications;    Sestrin2;    oxidative stress;    mitochondrial function;   

DOI  :  10.3389/fendo.2023.1274686

 received in 2023-08-08, accepted in 2023-10-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Diabetes is a global health problem which is accompanied with multi-systemic complications. It is of great significance to elucidate the pathogenesis and to identify novel therapies of diabetes and diabetic complications. Sestrin2, a stress-inducible protein, is primarily involved in cellular responses to various stresses. It plays critical roles in regulating a series of cellular events, such as oxidative stress, mitochondrial function and endoplasmic reticulum stress. Researches investigating the correlations between Sestrin2, diabetes and diabetic complications are increasing in recent years. This review incorporates recent findings, demonstrates the diverse functions and regulating mechanisms of Sestrin2, and discusses the potential roles of Sestrin2 in the pathogenesis of diabetes and diabetic complications, hoping to highlight a promising therapeutic direction.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Luo, Li, Lin, Li and Li