Correlation between the rate of morphological changes and rupture of intracranial aneurysms during one cardiac cycle analyzed by 4D-CTA

Frontiers in Neurology

Neurology

Sheng Qiu¹  Chengen Shen¹  Yuntao Li¹  Zhongzhou Su¹  Xiaohu Nie¹  Binghao Wang²  Jingjing Zhao³ 

[1]Department of Neurosurgery, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China

[2]Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation, Huzhou, China

[3]Department of Neurosurgery, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China

[4]Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation, Huzhou, China

[5]Department of Neurosurgery, Fourth Affiliated Hospital of Harbin Medical University, Harbin, China

[6]Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation, Huzhou, China

[7]Department of Hospital Infection Control, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China

关键词: 4D-CTA;    intracranial aneurysm;    morphological change rate;    rupture factors;    cardiac cycle;   

DOI  :  10.3389/fneur.2023.1235312

 received in 2023-06-08, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThis study aimed to analyze the relationship between the rate of morphological changes and intracranial aneurysm rupture during the cardiac cycle.MethodsEighty-four patients with intracranial aneurysms were retrospectively analyzed and divided into the rupture (42 cases) and unruptured (42 cases) groups. Four-dimensional computed tomography angiography (4D-CTA) was performed to collect quantitative parameters of aneurysm morphology and calculate the morphological change rate. The potential factors associated with aneurysm rupture were determined by comparing the general clinical data and rate of change in the location and morphology of the aneurysm between the two groups.ResultsEach morphological change rate in the rupture group was generally higher than that of the unruptured group. The rate of dome height change and aneurysm volume change were independent factors associated with aneurysm rupture. ROC curve analysis revealed that the diagnostic accuracy of the aneurysm volume change rate was higher. When the volume change rate was 12.33%, the sensitivity and specificity of rupture were 90.5 and 55.8%, respectively.ConclusionThe rate of change in dome height and volume of intracranial aneurysms during one cardiac cycle were independent factors associated with aneurysm rupture.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Shen, Su, Nie, Zhao, Qiu and Li.