STING in tumors: a focus on non-innate immune pathways

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Yiran Liu¹  Baofeng Guo¹  Jicheng Sun¹  Jiaying Yang²  Mei Yang³  Yingtong Wang³  Ling Zhang³ 

[1] Department of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China;Department of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China;Key Laboratory of Pathobiology, Ministry of Education, and Department of Biomedical Science, College of Basic Medical Sciences, Jilin University, Changchun, China;Key Laboratory of Pathobiology, Ministry of Education, and Department of Biomedical Science, College of Basic Medical Sciences, Jilin University, Changchun, China;

关键词: mtDNA;    cGAS-STING;    PD-L1;    TME;    extracellular vesicles;   

DOI  :  10.3389/fcell.2023.1278461

 received in 2023-08-16, accepted in 2023-10-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating innate immunity by promoting the release of interferon and other inflammatory factors. Mitochondrial DNA (mtDNA) with a double-stranded structure has greater efficiency and sensitivity in being detected by DNA sensors and thus has an important role in the activation of the cGAS-STING pathway. Many previous findings suggest that the cGAS-STING pathway-mediated innate immune regulation is the most important aspect affecting tumor survival, not only in its anti-tumor role but also in shaping the immunosuppressive tumor microenvironment (TME) through a variety of pathways. However, recent studies have shown that STING regulation of non-immune pathways is equally profound and also involved in tumor cell progression. In this paper, we will focus on the non-innate immune system pathways, in which the cGAS-STING pathway also plays an important role in cancer.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Yang, Wang, Sun, Liu, Zhang and Guo.