Frontiers in Cell and Developmental Biology | |
STING in tumors: a focus on non-innate immune pathways | |
Cell and Developmental Biology | |
Yiran Liu1  Baofeng Guo1  Jicheng Sun1  Jiaying Yang2  Mei Yang3  Yingtong Wang3  Ling Zhang3  | |
[1] Department of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China;Department of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun, China;Key Laboratory of Pathobiology, Ministry of Education, and Department of Biomedical Science, College of Basic Medical Sciences, Jilin University, Changchun, China;Key Laboratory of Pathobiology, Ministry of Education, and Department of Biomedical Science, College of Basic Medical Sciences, Jilin University, Changchun, China; | |
关键词: mtDNA; cGAS-STING; PD-L1; TME; extracellular vesicles; | |
DOI : 10.3389/fcell.2023.1278461 | |
received in 2023-08-16, accepted in 2023-10-13, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating innate immunity by promoting the release of interferon and other inflammatory factors. Mitochondrial DNA (mtDNA) with a double-stranded structure has greater efficiency and sensitivity in being detected by DNA sensors and thus has an important role in the activation of the cGAS-STING pathway. Many previous findings suggest that the cGAS-STING pathway-mediated innate immune regulation is the most important aspect affecting tumor survival, not only in its anti-tumor role but also in shaping the immunosuppressive tumor microenvironment (TME) through a variety of pathways. However, recent studies have shown that STING regulation of non-immune pathways is equally profound and also involved in tumor cell progression. In this paper, we will focus on the non-innate immune system pathways, in which the cGAS-STING pathway also plays an important role in cancer.
【 授权许可】
Unknown
Copyright © 2023 Yang, Yang, Wang, Sun, Liu, Zhang and Guo.
【 预 览 】
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