The role of cellular senescence in metabolic diseases and the potential for senotherapeutic interventions

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Lei Zhang¹  Yiyi Sun²  Yi Zhou²  Yuke Zhang²  Huantong Zhang²  Dayong Zhang²  Xin Shen²  Xingchen Lin²  Han Zhou² 

[1] School of Economy and Management, Zhejiang Sci-Tech University, Hangzhou, China;Taizhou Hospital of Zhejiang Province, Zhejiang University, Taizhou, China;School of Medicine, Hangzhou City University, Hangzhou, China;

关键词: cellular senescence;    metabolic disease;    diabetes mellitus;    SASP;    senolytic;   

DOI  :  10.3389/fcell.2023.1276707

 received in 2023-08-12, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cellular senescence represents an irreversible state of cell cycle arrest induced by various stimuli strongly associated with aging and several chronic ailments. In recent years, studies have increasingly suggested that the accumulation of senescent cells is an important contributor to the decline of organ metabolism, ultimately resulting in metabolic diseases. Conversely, the elimination of senescent cells can alleviate or postpone the onset and progression of metabolic diseases. Thus, a close relationship between senescent cells and metabolic diseases is found, and targeting senescent cells has emerged as an alternative therapy for the treatment of metabolic diseases. In this review, we summarize the role of cellular senescence in metabolic diseases, explore relevant therapeutic strategies for metabolic diseases by removing senescent cells, and provide new insights into the treatment of metabolic diseases.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Zhou, Shen, Lin, Zhang, Sun, Zhou, Zhang and Zhang.