Research progress of single-cell sequencing in tuberculosis

Frontiers in Immunology

Immunology

Qinzhou Dong¹  Jiahui Pan¹  Jingwei Shi¹  Xinyue Zhang¹  Zecheng Chang¹  He Zhao¹  Guoqing Wang¹ 

[1] Key Laboratory of Pathobiology Ministry of Education, College of Basic Medical Sciences/China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China;

关键词: single-cell sequencing;    scRNA-seq;    tuberculosis;    Mycobacterium tuberculosis;    host-pathogen interaction;   

DOI  :  10.3389/fimmu.2023.1276194

 received in 2023-08-14, accepted in 2023-09-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tuberculosis is a major infectious disease caused by Mycobacterium tuberculosis infection. The pathogenesis and immune mechanism of tuberculosis are not clear, and it is urgent to find new drugs, diagnosis, and treatment targets. A useful tool in the quest to reveal the enigmas related to Mycobacterium tuberculosis infection and disease is the single-cell sequencing technique. By clarifying cell heterogeneity, identifying pathogenic cell groups, and finding key gene targets, the map at the single cell level enables people to better understand the cell diversity of complex organisms and the immune state of hosts during infection. Here, we briefly reviewed the development of single-cell sequencing, and emphasized the different applications and limitations of various technologies. Single-cell sequencing has been widely used in the study of the pathogenesis and immune response of tuberculosis. We review these works summarizing the most influential findings. Combined with the multi-molecular level and multi-dimensional analysis, we aim to deeply understand the blank and potential future development of the research on Mycobacterium tuberculosis infection using single-cell sequencing technology.

【 授权许可】

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Copyright © 2023 Pan, Chang, Zhang, Dong, Zhao, Shi and Wang