Pathophysiology of spontaneous coronary artery dissection: hematoma, not thrombus

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Svetlana Apostolovic¹  Marija Marjanovic Haljilji²  Gordana Krljanac³  Predrag Matic⁴  Dusan Popovic⁵  Branka Filipovic⁵  Rastko Zivic⁶  Aleksandra Djokovic⁷  Vuk Djulejic⁸ 

[1] Coronary Care Unit, Cardiology Clinic, University Clinical Center of Nis, Nis, Serbia;Faculty of Medicine, University of Nis, Nis, Serbia;Department for Gastroenterology, Clinical Hospital Center Dr Dragisa Misovic “Dedinje”, Belgrade, Serbia;Faculty of Medicine, University of Belgrade, Belgrade, Serbia;Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia;Faculty of Medicine, University of Belgrade, Belgrade, Serbia;Clinic for Vascular Surgery, Institute for Cardiovascular Diseases “Dedinje”, Belgrade, Serbia;Faculty of Medicine, University of Belgrade, Belgrade, Serbia;Department for Gastroenterology, Clinical Hospital Center Dr Dragisa Misovic “Dedinje”, Belgrade, Serbia;Faculty of Medicine, University of Belgrade, Belgrade, Serbia;Department for Surgery, Clinical Hospital Center Dr Dragisa Misovic “Dedinje”, Belgrade, Serbia;Faculty of Medicine, University of Belgrade, Belgrade, Serbia;Department of Cardiology, University Hospital Center Bezanijska Kosa, Belgrade, Serbia;Faculty of Medicine, University of Belgrade, Belgrade, Serbia;Faculty of Medicine, Institute of Anatomy, Belgrade, Serbia;

关键词: spontaneous coronary artery dissection;    acute coronary syndrome;    pathophysiology;    women’s health;    pregnancy;    fibromuscular dysplasia;   

DOI  :  10.3389/fcvm.2023.1260478

 received in 2023-07-17, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Spontaneous coronary artery dissection (SCAD) accounts for 1.7%–4% of all acute coronary syndrome presentations, particularly among young women with an emerging awareness of its importance. The demarcation of acute SCAD from coronary atherothrombosis and the proper therapeutic approach still represents a major clinical challenge. Certain arteriopathies and triggers are related to SCAD, with high variability in their prevalence, and often, the cause remains unknown. The objective of this review is to provide contemporary knowledge of the pathophysiology of SCAD and possible therapeutic solutions.

【 授权许可】

Unknown   
© 2023 Djokovic, Krljanac, Matic, Zivic, Djulejic, Marjanovic Haljilji, Popovic, Filipovic and Apostolovic.