A cross-sectional study confirms temporary post-COVID-19 vaccine menstrual irregularity and the associated physiological changes among vaccinated women in Jordan

Frontiers in Medicine

Medicine

Ensaf Y. Almomani¹  Abass Al-Momany²  Ahmad Qablan³  Dima A. Sabbah⁴  Rima Hajjo⁵ 

[1] Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan;Applied Science Research Center, Applied Science Private University, Amman, Jordan;Department of Clinical Laboratory Sciences, University of Jordan, Amman, Jordan;Department of Curriculum and Methods of Instruction, United Arab Emirates University, Al Ain, United Arab Emirates;Faculty of Educational Sciences, Hashemite University, Zarqa, Jordan;Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan;Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan;Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;Jordan CDC, Amman, Jordan;

关键词: COVID-19 vaccine;    adverse events;    menstrual cycle irregularity;    vaccinated women;    Jordan;   

DOI  :  10.3389/fmed.2023.1211283

 received in 2023-05-05, accepted in 2023-08-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundCOVID-19 vaccines continue to save people’s lives around the world; however, some vaccine adverse events have been a major concern which slowed down vaccination campaigns. Anecdotal evidence pointed to the vaccine effect on menstruation but evidence from the adverse event reporting systems and the biomedical literature was lacking. This study aimed to investigate the physiological changes in women during menstruation amid the COVID-19 vaccination.MethodsA cross-sectional online survey was distributed to COVID-19 vaccinated women from Nov 2021 to Jan 2022. The results were analyzed using the SPSS software.ResultsAmong the 564 vaccinated women, 52% experienced significant menstrual irregularities post-vaccination compared to before regardless of the vaccine type. The kind of menstrual irregularity varied among the vaccinated women, for example, 33% had earlier menstruation, while 35% reported delayed menstruation. About 31% experienced heavier menstruation, whereas 24% had lighter menstrual flow. About 29% had menstruation last longer, but 13% had it shorter than usual. Noteworthy, the menstrual irregularities were more frequent after the second vaccine shot, and they disappeared within 3 months on average. Interestingly, 24% of the vaccinated women reported these irregularities to their gynecologist.ConclusionThe COVID-19 vaccine may cause physiological disturbances during menstruation. Luckily, these irregularities were short-termed and should not be a reason for vaccine hesitancy in women. Further studies are encouraged to unravel the COVID-19 vaccine adverse effect on women’s health.

【 授权许可】

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Copyright © 2023 Almomani, Hajjo, Qablan, Sabbah and Al-Momany.