Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis

Frontiers in Public Health

Public Health

Xu Sun¹  Te Bu²  Yang Zhang³  Lide Su⁴ 

[1] College of Physical Education, Hunan Normal University, Changsha, China;College of Physical Education, Hunan Normal University, Changsha, China;Institute of Sports and Health Industry, HEHA CAT Fitness, Changsha, China;Independent Person, Windermere, FL, United States;School of Humanities, Inner Mongolia University of Technology, Hohhot, China;Institute of Sports and Health Industry, HEHA CAT Fitness, Changsha, China;

关键词: cancer;    oxidative stress;    mitochondrial;    nicotinamide adenine dinucleotide;    nicotinamide mononucleotide;    nicotinamide phosphoribosyltransferase;    physical activity;   

DOI  :  10.3389/fpubh.2023.1287421

 received in 2023-09-01, accepted in 2023-09-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveAging is associated with decreased nicotinamide adenine dinucleotide (NAD) levels, which in turn cause dysfunctional mitochondria and indirectly affect a myriad of diseases. Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) serves as a central rate-limiting enzyme in NAD synthesis, making it an indispensable health mediator. This meta-analysis examined the effect of exercise training on the expression of iNAMPT in humans.MethodsWe searched PubMed, Scopus, ClinicalTrials.gov, and the International Clinical Trials Registry Platform for studies published between the inception of the database and July 5, 2023. Using the common-effect model, evidence for the change in iNAMPT following exercise training was synthesized as Cohen’s d.ResultsThe search yielded five eligible studies. The overall effect size is 0.81, with a 95% confidence interval of 0.55 to 1.07. Therefore, a random adult will have a 71.7% probability that iNAMPT will be up-regulated following exercise training. In general, exercise training resulted in a 1.46-fold increase in iNAMPT. Our probability statistics indicate that subgroups of interest may differ practically. Specifically, there is a 79.3% probability of increased iNAMPT in men, compared to a 69.0% probability in the overall population; young adults have a 75.6% probability of having an increased iNAMPT, whereas aged adults have a 68.7% probability; and, iNAMPT has a 75.1% probability increase after aerobic exercise and a 66.4% probability increase after resistance exercise.ConclusionExercise training is effective for increasing iNAMPT levels in skeletal muscles. This essential enzyme regulates not only cellular energetics but also healthspan. Therefore, exercise should be promoted as a natural slow-aging lifestyle.

【 授权许可】

Unknown   
Copyright © 2023 Sun, Su, Bu and Zhang.