期刊论文详细信息
Frontiers in Bioengineering and Biotechnology
Porous biomaterial scaffolds for skeletal muscle tissue engineering
Bioengineering and Biotechnology
Sydnee T. Sicherer1  Natalie G. Kozan1  Mrunmayi Joshi1  Jonathan M. Grasman2 
[1] Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States;null;
关键词: volumetric muscle loss;    biomaterial;    tissue engineering;    porosity;    scaffold;    skeletal muscle;    skeletal muscle tissue engineering;   
DOI  :  10.3389/fbioe.2023.1245897
 received in 2023-06-24, accepted in 2023-09-18,  发布年份 2023
来源: Frontiers
PDF
【 摘 要 】

Volumetric muscle loss is a traumatic injury which overwhelms the innate repair mechanisms of skeletal muscle and results in significant loss of muscle functionality. Tissue engineering seeks to regenerate these injuries through implantation of biomaterial scaffolds to encourage endogenous tissue formation and to restore mechanical function. Many types of scaffolds are currently being researched for this purpose. Scaffolds are typically made from either natural, synthetic, or conductive polymers, or any combination therein. A major criterion for the use of scaffolds for skeletal muscle is their porosity, which is essential for myoblast infiltration and myofiber ingrowth. In this review, we summarize the various methods of fabricating porous biomaterial scaffolds for skeletal muscle regeneration, as well as the various types of materials used to make these scaffolds. We provide guidelines for the fabrication of scaffolds based on functional requirements of skeletal muscle tissue, and discuss the general state of the field for skeletal muscle tissue engineering.

【 授权许可】

Unknown   
Copyright © 2023 Kozan, Joshi, Sicherer and Grasman.

【 预 览 】
附件列表
Files Size Format View
RO202311145146730ZK.pdf 1592KB PDF download
  文献评价指标  
  下载次数:8次 浏览次数:3次