Causal association between adiposity and hemorrhoids: a Mendelian randomization study

Frontiers in Medicine

Medicine

Hongping Qin¹  Ying Gui¹  Jian Huang¹  Yubo Xie² 

[1]Clinical Laboratory Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

[2]Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

[3]Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

关键词: adiposity;    hemorrhoids;    Mendelian randomization;    risk;    body mass index;   

DOI  :  10.3389/fmed.2023.1229925

 received in 2023-05-27, accepted in 2023-09-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundHemorrhoids are a very common anorectal disorder affecting a large number of individuals throughout the world. This study aimed to evaluate the causal effects of four adiposity traits including body mass index (BMI), body fat percentage, waist circumference, and waist-to-hip ratio on hemorrhoids by Mendelian randomization (MR).MethodsWe used summary statistics of BMI (N = 461,460), body fat percentage (N = 454,633), waist circumference (N = 462,166), waist-to-hip ratio (N = 212,244), and hemorrhoids (N = 337,199) from large-scale genome wide association studies of European ancestry. Univariable and multivariable MR were carried out to infer causality. The MR Steiger directionality test was used to test the causal direction.ResultsThe primary MR analysis using the inverse variance weighted (IVW) method showed that there were positive effects of genetically determined BMI [odds ratio (OR) = 1.005, 95% confidence interval (CI): 1.003–1.008, per standard deviation (SD), p = 7.801 × 10−5], body fat percentage (OR = 1.005, 95% CI: 1.001–1.008, per SD, p = 0.008), waist circumference (OR = 1.008, 95% CI: 1.005–1.011, per SD, p = 1.051 × 10−6), and waist-to-hip ratio (OR = 1.010, 95% CI: 1.003–1.017, per SD, p = 0.003) on hemorrhoids. These findings were robust in multivariable MR adjusting for physical activity. The Steiger directionality test showed evidence against reverse causation.ConclusionOur MR study supports a causal role of adiposity in the development of hemorrhoids. Adiposity prevention may be an important strategy for reducing hemorrhoids risk.

【 授权许可】

Unknown   
Copyright © 2023 Huang, Gui, Qin and Xie.